Diagnosing autism spectrum disorder (ASD) can be complicated, since there is no blood test or other medical procedure that can easily identify the developmental disorder, which is characterized by difficulties with social interaction and communication and restricted and repetitive behavior. 

Doctors look at the child’s behavior and development to make a diagnosis of ASD, which can sometimes be detected at 18 months or younger. But the easier it is diagnosed and treated, the better. Since many children do not get a final diagnosis until they’re much older, the delay means that ASD sufferers might not get the help they need.

Until, ASD patients have been diagnosed using developmental screening (a short test to see if the child is learning basic skills on time) and a comprehensive diagnostic evaluation (a thorough review of the the child’s behavior and development and interviewing the parents, plus a hearing and vision exam, genetic testing and neurological examination. 

The specialists who usually perform such screening over a period or weeks or months are developmental pediatricians, pediatric neurologists or child psychologists or psychiatrists. 

But the diagnosis can be made much simpler, according to experts at Ben-Gurion University of the Negev (BGU) in Beersheba. A new study just published in Autism Research shows that measuring a child’s gaze patterns as he or she watches movies of social interactions is a reliable way to accurately identify nearly half of ASD) cases. 

 “Eye tracking is likely to be one of the first technologies that will be incorporated into clinical use for assessment of ASD symptoms, but it needs to be optimized to identify and quantify specific ASD symptoms,” stated Prof. Ilan Dinstein of BGU’s departments of psychology and cognitive and brain sciences and director of Israel’s National Autism Research Center. “This new study takes a first important step in this direction using eye tracking technology to compare different movies and measures within the same group of children,” he added. 

According to the US Center for Disease Control (CDC), one in 59 children in the US has ASD. It is much more common in boys than girls. Generally, when normally developing children watch movies of social interactions, they do so in a reliable and predictable manner, observing faces, gestures, body movements and objects that are relevant to the social interaction and its narrative. 

In the new study, however, the researchers show that children with ASD watch such movies with significantly more variable and idiosyncratic gaze patterns. Previous eye tracking studies have reported that children with ASD fixate less on faces in comparison to control groups – but children must also gaze at actions, gestures, body movements, contextual details and objects that are part of the social narrative, thereby creating complex gaze patterns to properly understand social interactions. 

In the new BGU study, the researchers presented 70ASD children and a control group of 40 unaffected children with three short movies, each shown twice. Two of the movies were animations while one was a realistic home video; all contained social interactions between at least two individuals. This experimental design allowed comparisons across movies, presentations and different eye tracking measures to identify what is the best technique for identifying ASD children based on differences in gaze behavior. 

Since children watch movies in a predictable manner, the gaze pattern of individual children is remarkably similar to the mean gaze pattern of their group. In other words, typically developing children agree on where and when to look at specific locations in the frame. 

In contrast, children with ASD exhibited significantly more variable/idiosyncratic gaze patterns that differed from the average gaze pattern of the typically developing children. Moreover, their gaze patterns were remarkably inconsistent not only between individuals, but also across movie presentations. Thus, when children with ASD watch the same movie repeatedly, they have more variable and inconsistent gaze patterns. 

“Quantifying this gaze idiosyncrasy in individual children enabled separation of ASD and control children with higher sensitivity and specificity than traditional measures such as time gazing at faces,” Dinstein explained. “It was also strongly correlated with their social symptom’s severity.” 

The largest differences across ASD and control groups were clear when using a realistic video containing a social interaction between two sisters (two and five years old) in a messy room with everyday objects. This suggests that abnormal, idiosyncratic gaze patterns were most pronounced when ASD children observed real-life unedited interactions of other children. This makes the findings particularly relevant to real-life social situations.

“Taken together, these results demonstrate that ASD children with more severe symptoms exhibit larger gaze idiosyncrasy,” Dinstein concluded. “This can aid not only in early detection of autism, but also in assessing changes in ASD severity over time and in response to treatments. Such measures, which objectively measure symptoms directly from the child, are critically lacking in today’s clinical trials of autism treatments.” 


Source: Israel in the News